RESUMO
Antecedentes. La paracoccidioidomicosis es la micosis sistémica más frecuente en las zonas tropicales y subtropicales de Latinoamérica; el agente etiológico es Paracoccidioides. La enfermedad se presenta preferentemente en la población adulta, por lo que existen pocos reportes en la edad pediátrica. El objetivo del presente trabajo es describir las características clínicas, epidemiológicas y diagnósticas, y la evolución de los casos de paracoccidioidomicosis diagnosticados en el Hospital de Pediatría Prof. Dr. Juan P. Garrahan entre los años 2000 y 2010. Casos clínicos. Se presentan los casos de 4 pacientes previamente sanos procedentes del norte argentino con paracoccidioidomicosis diseminada juvenil y diagnóstico confirmatorio anatomopatológico o microbiológico. Conclusiones. La paracoccidioidomicosis debe ser considerada dentro de los diagnósticos diferenciales en niños con síndrome febril y compromiso linfoganglionar, acompañado por anemia, hipereosinofilia e hipergammaglobulinemia, procedentes de áreas endémicas del país (AU)
Background. Paracoccidioidomycosis is the most frequent systemic mycosis in Latin America, caused by the dimorphic fungus Paracoccidioides. Paracoccidioidomycosis in children is uncommon. Our aim is to describe clinical features of patients who had a confirmed diagnosis of paracoccidioidomycosis in our hospital in the last 10 years. Case reports. We describe 4 cases of paracoccidioidomycosis in previously healthy children from the north of our country. Diagnoses were made by biopsy or culture. Conclusions. The diagnosis of paracoccidioidomycosis should be considered in a patient coming from regions where Paracoccidioides is endemic, and presenting with a lymphoproliferative syndrome, anemia, eosinophilia and hypergammaglobulinemia (AU)
Assuntos
Humanos , Masculino , Feminino , Criança , Paracoccidioidomicose/complicações , Paracoccidioidomicose/microbiologia , Micoses/epidemiologia , Micoses/prevenção & controle , Diagnóstico Diferencial , Hipergamaglobulinemia/complicações , Hipergamaglobulinemia/diagnóstico , Paracoccidioidomicose/epidemiologia , Infecções Fúngicas do Sistema Nervoso Central/complicações , Infecções Fúngicas do Sistema Nervoso Central/epidemiologia , Eosinofilia/microbiologiaRESUMO
BACKGROUND: Paracoccidioidomycosis is the most frequent systemic mycosis in Latin America, caused by the dimorphic fungus Paracoccidioides. Paracoccidioidomycosis in children is uncommon. Our aim is to describe clinical features of patients who had a confirmed diagnosis of paracoccidioidomycosis in our hospital in the last 10 years. CASE REPORTS: We describe 4 cases of paracoccidioidomycosis in previously healthy children from the north of our country. Diagnoses were made by biopsy or culture. CONCLUSIONS: The diagnosis of paracoccidioidomycosis should be considered in a patient coming from regions where Paracoccidioides is endemic, and presenting with a lymphoproliferative syndrome, anemia, eosinophilia and hypergammaglobulinemia.
